The purpose of this article is to present the main issues associated with the creation of the supraregional strategy on the example of Western Poland. It is in the first part of the study that there were presented external conditions for the cooperation arising from the regulations of the most important European and Polish program documents of the time horizon up to 2020. The next part presents synthetic social and economic characterization of the macro-region of Western Poland. Subsequently, the concept and the objectives for the creation of the supraregional strategy were presented. It is at present that the Development Strategy for Western Poland and the Development Strategy for Southern Poland for the Śląskie and Małopolskie Voivodeships are being created. These initiatives are bottom-up actions of the self-government bodies of the voivodeships that allows for implementing the model of the multilevel governance and the strategic partnership of the domestic and regional system. These are the first cooperation projects amongst macro-regions in Poland initiated from the bottom up and voluntarily by self-government authorities, in which the voivodeships acknowledge that their development should take place through joint actions taken in the entire macro-region and creating the synergy effect. These are very innovative actions against the background of the experience at programming the regional development in Poland.